CAS NO: | 1446113-23-0 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Belvarafenib (HM95573) is a potent and panRAF(Rapidly Accelerated Fibrosarcoma) inhibitor, withIC50sof 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600EandC-RAFrespectively[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600Eand C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 478.93 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C23H16ClFN6OS | ||||||||||||||||
CAS 号 | 1446113-23-0 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 12.5 mg/mL(26.10 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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