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HOAt
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
HOAt图片
CAS NO:39968-33-7
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
25g电议
100g电议

产品介绍

coupling activator for racemization-free coupling in peptide synthesis

Cas No.39968-33-7
别名N-羟基-7-氮杂苯并三氮唑
化学名3-hydroxytriazolo[4,5-b]pyridine
Canonical SMILESC1=CC2=C(N=C1)N(N=N2)O
分子式C5H4N4O
分子量136.11
溶解度≥ 6.8mg/mL in DMSO, ≥ 9.29 mg/mL in EtOH with ultrasonic, ≥ 3.62 mg/mL in Water with ultrasonic
储存条件Desiccate at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

A coupling activator for racemization-free coupling in peptide synthesis; An additive for peptide segment coupling in in reducing the extent of configurational loss at the reactive carboxylic acid residue. Carpino L A etc. works demonstrated that the DIC/HOAt system is more effective in preserving configuration for peptide segment coupling than the analogous DIC/HOBt system

in DMF and DCM. [1]

Reference:
[1].Carpino L A, El-Faham A. The diisopropylcarbodiimide/1-hydroxy-7-azabenzotriazole system: segment coupling and stepwise peptide assembly[J]. Tetrahedron, 1999, 55(22): 6813-6830.