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Mtb ATP synthase-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mtb ATP synthase-IN-1图片
CAS NO:2642394-38-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Mtb ATP synthase-IN-1 (compound 6ab) 是一种有效的结核分枝杆菌 (Mtb) ATP 合成抑制剂,对Mtb的 MIC 为 0.452 ~ 0.499 μg/mL。Mtb ATP synthase-IN-1 代谢稳定性好,细胞毒性低 (Vero IC50>64 μg/mL),具有一定的口服生物利用度。Mtb ATP synthase-IN-1 可用于抗结核分枝杆菌的研究。
生物活性

Mtb ATP synthase-IN-1 (compound 6ab) is a potentMycobacterium tuberculosis(Mtb)ATP synthaseinhibitor, with MIC of 0.452-0.499 μg/mL againstMtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC50>64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium[1].

IC50& Target

MIC: 0.452-0.499 μg/mL (Mtb)[1]

体内研究
(In Vivo)

Mtb ATP synthase-IN-1 (50 mg/kg for PO, 5 mg/kg for IV; single dosage) exhibits good metabolic stability and acceptable oral bioavailability[1].
Pharmacokinetic Parameters of Mtb ATP synthase-IN-1 in male CD-1 mouse[1].

PO (50 mg/kg)IV (5 mg/kg)
Cmax(ng/mL)13331241
Tmax(h)0.83
T1/2(h)0.510.33
AUC0-t(ng/mL·h)21971667
AUC0-∞(ng/mL·h)21981672
MRT0-∞(ng/mL)1.360.28
CL (mL/min/kg)51.4
F (%)13.1

Animal Model:Male CD-1 mouse[1]
Dosage:50 and 5 mg/kg
Administration:50 mg/kg for PO, 5 mg/kg for IV; single dosage (Pharmacokinetics Analysis)
Result:Exhibited good metabolic stability and acceptable oral bioavailability.
分子量

323.30

Formula

C17H13N3O4

CAS 号

2642394-38-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.