CAS NO: | 1699720-89-2 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | ML753286 is an orally active and selectiveBCRP(Breastcancerresistance protein)inhibitor with anIC50of 0.6 μM. ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions, and is stable in plasma cross species[1]. | ||||||||||||
IC50& Target | IC50: 0.6 μM (BCRP)[1] | ||||||||||||
体外研究 (In Vitro) | ML753286 has IC50values of >30, 0.6, and 39.0 μM for the inhibition of P-gp-, BCRP-, and OATP mediated transport, respectively[1]. | ||||||||||||
体内研究 (In Vivo) | ML753286 (25- or 50-mg/kg (PO); 10 or 20 mg/kg (IV); 0.083-24 hours) appears to completely inhibit Bcrp functions in rats at 25 mg/kg PO or at 20 mg/kg IV. The tmaxvalues in plasma were 1.4, 4.0, and 4.1 hours in Bcrp KO rats, WT rats pre-administered 25-mg/kg ML753286, and WT rats pre-administered 50-mg/kg ML753286, respectively[1].
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分子量 | 355.43 | ||||||||||||
性状 | Solid | ||||||||||||
Formula | C20H25N3O3 | ||||||||||||
CAS 号 | 1699720-89-2 | ||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||
储存方式 |
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