Fuscin，一种真菌代谢物，具有抗 HIV 作用的 CCR5 受体拮抗剂。
| Cas No. | 83-85-2 |
| 别名 | 暗褐菌素 |
| Canonical SMILES | O=C1OC(C)C(C2=C1)=C(O)C(C3=C2CCC(C)(C)O3)=O |
| 分子式 | C15H16O5 |
| 分子量 | 276.3 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities. It inhibits binding of the ADP/ATP translocase inhibitor atractyloside to rat liver mitochondria in an ADP-dependent manner when used at a concentration of 50 μM in a radioligand binding assay. Fuscin (20 μM) reduces the glutathione content of rat liver mitochondria to 28% of controls and inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations in a concentration-dependent manner. It competes with macrophage inflammatory protein 1α (MIP-1α) for binding to CCR5 chemokine receptors in vitro with an IC50 value of 21 μM. |
m.cnreagent.com