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Genkwanin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Genkwanin图片
CAS NO:437-64-9
包装:20mg
市场价:1439元

产品介绍
Genkwanin 是一种主要的非糖基化黄酮类化合物,具有抗炎活性。
Cas No.437-64-9
别名芫花素,Puddumetin
化学名5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychromen-4-one
Canonical SMILESCOC1=CC(=C2C(=C1)OC(=CC2=O)C3=CC=C(C=C3)O)O
分子式C16H12O5
分子量284.26
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Genkwanin is a major non-glycosylated flavonoid with anti-flammatory activities.

Cell viability analysis shows that Genkwanin does not affect the cell viability up to a concentration of 50 μM. Genkwanin inhibits the LPS-induced production of NO in a concentration-dependent manner. iNOS only expresses in the present of external stimulus. Genkwanin could not significantly affect the activity of iNOS. The effect of Genkwanin on the production of proinflammatory cytokines is examined. Genkwanin suppresses the productions of TNF-a, IL-1b and IL-6 in LPS stimulated RAW264.7 macrophages in a concentration-dependent manner. Genkwanin significantly suppresses the AP-1 signaling pathway but has little effect on the NF-kB signaling pathway. It is indicated that Genkwanin suppresses the phosphorylation of p38 and JNK in a concentration-dependent manner, but little affects ERK1/2 phosphorylation. Originally identified as an immediate early gene, MKP-1 is then found to be a dual specificity phosphatase acting as a negative regulator of ERK1/2, JNK and p38 MAPK activities, with predominant effects on the latter two. Pretreatment with Genkwanin markedly up-regulates the expression of MKP-1 without affecting MKP-1 mRNA[1].

References:
[1]. Gao Y et al. Genkwanin inhibits proinflammatory mediators mainly through the regulation of miR-101/MKP-1/MAPK pathway in LPS-activated macrophages. PLoS One. 2014 May 6;9(5):e96741.