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Glycerol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Glycerol图片
包装与价格:
包装价格(元)
100mL电议
200mL电议
500mL电议

产品介绍
Glycerol是透明,无色,粘稠的甜味液体。甘油可用于聚丙烯酰胺凝胶电泳的样品制备和凝胶形成。

Animal experiment:

Rats: Experimental acute renal failure was induced in male Wistar rats 230-300 g by an injection of glycerol dissolved in saline (50% v/v, 10 mL/kg) into the leg muscle after a 24-h period of water deprivation[3].

产品描述

Glycerol is a clear, colourless, viscous, sweet-tasting liquid. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis. Human Endogenous Metabolite

Glycerol is often included in polyacrylamide gels to prevent dissociation of nucleosomes and other protein-DNA complexes during electrophoresis. With glycerol included, fractionation seems to be largely based on particle mass and charge. The concentration of glycerol during electrophoresis strongly affects the separation characteristics of polyacrylamide gels[1]. Glycerol is an inevitable by-product of oils/fats processing, regardless of the pathway. Fermentative metabolism of glycerol has been studied in great detail in several species of the Enterobacteriaceae family, such as Citrobacter freundii and Klebsiella pneumoniae. The use of anaerobic fermentation to convert abundant and low-priced glycerol streams generated in the production of biodiesel into higher value products represents a promising route to achieve economic viability in the biofuels industry[2].

Glycerol can induce acute renal failure in rat models. Acute renal failure induced by glycerol or uranyl nitrate reduces the hepato-biliary transport of some drugs, modulates the distribution of drugs into the central nervous system and affects the activity of various hepatic microsomal enzymes [3].

[1]. Pennings S, et al. Effect of glycerol on the separation of nucleosomes and bent DNA in low ionic strengthpolyacrylamide gel electrophoresis. Nucleic Acids Res. 1992 Dec 25;20(24):6667-72. [2]. Yazdani SS, et al. Anaerobic fermentation of glycerol: a path to economic viability for the biofuelsindustry. Curr Opin Biotechnol. 2007 Jun;18(3):213-9. [3]. Huang ZH, et al. Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure. Eur J Pharmacol. 2000 Oct 20;406(3):453-60.