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Atreleuton
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Atreleuton图片
CAS NO:154355-76-7
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Atreleuton (ABT-761) 是一种选择性的、可逆的、口服可生物利用的 5-脂加氧酶 (5-LO) 抑制剂。Atreleuton (ABT-761) 有效选择性的抑制白三烯形成。
Cas No.154355-76-7
别名ABT-761; VIA-2291
Canonical SMILESO=C(N)N([C@H](C)C#CC1=CC=C(CC2=CC=C(F)C=C2)S1)O
分子式C16H15FN2O2S
分子量318.37
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Atreleuton (ABT-761) is a selective, reversible, and orally bioavailable 5-Lipoxygenase (5-LO) inhibitor. Atreleuton (ABT-761) exhibits potent and selective inhibition of leukotriene formation[1][2][3]. 5-LO[1]

[1]. VIA Pharmaceuticals Meets With FDA to Discuss Next Steps For VIA-2291 and Phase 3 Outcome Trial in Cardiovascular Disease. VIA Pharmaceuticals, Inc. [2]. Reid JJ, et al. ABT-761 (Abbott). Curr Opin Investig Drugs. 2001 Jan;2(1):68-71. [3]. Bell RL, et al. ABT-761 attenuates bronchoconstriction and pulmonary inflammation in rodents. J Pharmacol Exp Ther. 1997 Mar;280(3):1366-73.