CAS NO: | 1068-84-4 |
包装 | 价格(元) |
10mg | 电议 |
50mg | 电议 |
Cas No. | 1068-84-4 |
别名 | 氨基丙二酸 |
Canonical SMILES | O=C(O)C(N)C(O)=O |
分子式 | C3H5NO4 |
分子量 | 119.08 |
溶解度 | Water: 8.33 mg/mL (69.95 mM) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Aminomalonic acid is an amino endogenous metabolite, acts as a strong inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR (Ki= 0.0023 M) and mouse pancreas (Ki= 0.0015 M) in vitro. Aminomalonic acid is a potential biomarker to discriminate between different stages of melanoma metastasis[1][2][3]. Ki: 0.0023 M (L-asparagine synthetase from Leukemia 5178Y/AR), 0.0015 M (L-asparagine synthetase from mouse pancreas)[2] [1]. Van Buskirk JJ, et al. Aminomalonic acid: identification in Escherichia coli and atherosclerotic plaque. Proc Natl Acad Sci U S A. 1984 Feb;81(3):722-5. [2]. Milman HA, et al. Aminomalonic acid and its congeners as potential in vivo inhibitors of L-asparagine synthetase. Enzyme. 1979;24(1):36-47. [3]. Kim HY, et al. Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling. Sci Rep. 2017 Aug 18;7(1):8864. |