γ-Aminobutyric acid

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γ-Aminobutyric acid

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

56-12-2

包装与价格：

包装	价格(元)
10 mM * 1 mL in Water	电议
100mg	电议
200mg	电议
500mg	电议

产品名称

γ-氨基丁酸
4-Aminobutyric acid

产品介绍

γ-Aminobutyric acid (4-Aminobutyric acid) 是成年哺乳动物大脑中主要的抑制性神经递质，能够与离子移变GABA_A受体和促代谢GABA_B受体结合发挥作用。γ-Aminobutyric acid 能够阻断中枢神经系统的特定信号，并带来镇静效果。

生物活性

γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABA_Areceptors) and metabotropic receptors (GABA_Breceptors. γ-Aminobutyric acid shows calming effect by blocking specific signals of central nervous system^[1]^[2].

IC₅₀& Target

Human Endogenous Metabolite

Microbial Metabolite

体外研究
(In Vitro)

γ-Aminobutyric acid (30 μM) depolarizes cortical progenitor cells (E16 cells), results an inward current in ventricular zone (VZ) cells, and induces DNA synthesis inhibition, with half-maximal response concentration of 5 μM^[3].
Cortical plate (cp) neurons expresses glutamic acid decarboxylase (GAD), γ-Aminobutyric acid (1-5 μM; 18 h) stimulates the motility and arrests the migration of cp cells, while the chemotropic signal is involved G-protein activation^[4].
γ-Aminobutyric acid activates GABA_Areceptors, causing cell cycle arrest in S phase and limiting growth^[5].

Cell Migration Assay^[4]

Cell Line:	Cortical plate (cp) neurons
Concentration:	1-5 μM
Incubation Time:	18 hours
Result:	Promoted motility via G-protein activation and arrested attractantinduced migration via GABAA receptor-mediated depolarization.

体内研究
(In Vivo)

γ-Aminobutyric acid (33.95, 102.25, 306.75 mg/kg; p.o.; single dose) can enhance the sleep of mice^[6].
γ-Aminobutyric acid (1, 2, 4 mg/kg/d; p.o.; 30 d) alleviates anxiety and restored food utilization rate in rats, with impairment induced by Di(2-ethylhexyl) phthalate (DEHP) exposure^[7].

Animal Model:	Pathogens free (SPF) Bagg’s albino (Balb/c) mice (18–20 g, 8 weeks old)^[6]
Dosage:	33.95, 102.25, 306.75 mg/kg
Administration:	Oral gavage; single dose; 20 mL/kg administration; measured in an hour
Result:	Prolonged the sleep duration, increased sleep rate, and shorten the sleep latency more effectively.

Animal Model:	Sprague-Dawley rat indued byDEHP(HY-B1945) (500 mg/kg)^[7]
Dosage:	1, 2, 4 mg/kg
Administration:	Oral gavage; combined administration; for 30 consecutive days
Result:	Reduced the levels of nitric oxide and nitric oxide synthase in rats treated with DEHP.

分子量

103.12

性状

Solid

Formula

C₄H₉NO₂

CAS 号

56-12-2

中文名称

γ-氨基丁酸

结构分类

Ketones, Aldehydes, Acids

来源

mammalian central nervous system

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 50 mg/mL(484.87 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	9.6974 mL	48.4872 mL	96.9744 mL
5 mM	1.9395 mL	9.6974 mL	19.3949 mL
10 mM	0.9697 mL	4.8487 mL	9.6974 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (969.74 mM); Clear solution; Need ultrasonic and warming and heat to 60℃

*以上所有助溶剂都可在本网站选购。