Terrein 是一种黑色素生成抑制剂。 Terrein 在乳腺癌细胞系中诱导细胞凋亡。 Terrein 是铜绿假单胞菌中群体感应和 c-di-GMP 的抑制剂。
| Cas No. | 582-46-7 |
| 别名 | 土曲霉酮 |
| 化学名 | 4S,5R-dihydroxy-3-(1E)-1-propen-1-yl-2-cyclopenten-1-one |
| Canonical SMILES | O=C1[C@H](O)[C@@H](O)C(/C=C/C)=C1 |
| 分子式 | C8H10O3 |
| 分子量 | 154.2 |
| 溶解度 | DMSO: Soluble,Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Terrein is a fungal metabolite produced by A. terreus with diverse biological activities. It reduces melanin production in Mel-Ab mouse melanocytes in a dose-dependent manner via ERK activation and downregulation of microphthalmia-associated transcription factor (MITF). Terrein inhibits proliferation of human keratinocytes and thins the epidermis in a skin equivalent model of psoriasis vulgaris. It is antimicrobial, inhibiting the growth of S. aureus, A. hydrophila, E. faecalis, A. flavus, A. alternata, B. sorokiniana, and P. drechsleri (MICs = 1-40 μg/ml). Terrein also inhibits growth of A549 lung cancer cells in a dose-dependent manner. |
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