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GZ-793A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GZ-793A图片
CAS NO:1356447-90-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
GZ-793A 是一种具有口服活性和选择性的囊泡单胺转运体-2 (VMAT2) 抑制剂,其Ki值为 0.029 μM。GZ-793A 能抑制甲基苯丙胺 (METH) 诱导的多巴胺释放,可用于 METH 成瘾研究。
生物活性

GZ-793A is an orally active and selectivevesicular monoamine transporter-2 (VMAT2)inhibitor, with anKiof 0.029 μM. GZ-793A inhibits the neurochemical effects of methamphetamine (METH)-induced dopamine release. GZ-793A can be used for research of METH addiction[1][2][3].

IC50& Target

Ki: 0.029 μM (VMAT2)[1].

体内研究
(In Vivo)

GZ-793A (30, 60, 120 or 240 mg/kg; p.o.; once) decreases the number of METH infusions self-administered across each time interval evaluats in a dose-dependent manner[1].
GZ-793A (1-100 μM; 90 min) inhibits METH (5 μM)-evoked fractional dopamine releases[2].

Animal Model:Adult male Sprague-Dawley rats[1].
Dosage:30, 60, 120 or 240 mg/kg
Administration:Oral administration; once.
Result:Decreased the number of METH infusions self-administered in a dose-dependent manner, and with an ~85% reduction at the highest dose (240 mg/kg).
Decreased the METH self-administration produced by lasted at least 180 min.
Animal Model:Male Sprague-Dawley rats (250–275 g; 9-week-old; 0.5 mm thick rats coronal striatal slices are used)[2].
Dosage:1-100 μM
Administration:90 min
Result:Inhibited methamphetamine-evoked dopamine released in a concentration-dependent manner.
分子量

464.04

Formula

C26H38ClNO4

CAS 号

1356447-90-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.