MCT1-IN-3

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MCT1-IN-3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2878360-80-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

MCT1-IN-3 是一种单羧酸转运蛋白 1(MCT1)抑制剂，IC₅₀值为 81.0 nM。MCT1-IN-3 还对多药转运蛋白ABCB1具有显著的抑制作用。MCT1-IN-3 可用于癌症的研究。

生物活性

MCT1-IN-3 is amonocarboxylate transporter1 (MCT1)inhibitor with anIC₅₀value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporterABCB1. MCT1-IN-3 can be used for the research ofcancer^[1].

IC₅₀& Target

IC50: 81.0 nM (MCT1)^[1]
GI50: 20 μM (A-549); 15.1 μM (MCF-7)^[1]

体外研究
(In Vitro)

MCT1-IN-3 (compound 24) 对 MCT1 具有抑制活性，IC₅₀值为 81.0 nM^[1]。
MCT1-IN-3 对表达 MCT1 的癌细胞系 A-549 和 MCF-7 具有很强的抗增殖活性，GI₅₀值分别为 20 μM 和 15.1 μM^{[1]< /sup>.
MCT1-IN-3（5 μM；24 h）导致癌细胞周期停滞和细胞凋亡^[1]。
MCT1-IN-3（1.0、2.0、3.5 和 5.0 μM）显示可使这些癌细胞对抗肿瘤药物敏感^[1]。
MCT1-IN-3 还对多药转运蛋白 ABCB1 具有显著的抑制作用，并显示可逆转 ABCB1 介导的多药耐药性 (MDR)^[1]。}

Cell Cycle Analysis^[1]

Cell Line:	A-549 cells
Concentration:	5 μM
Incubation Time:	24 h
Result:	Caused a disruption of the cell cycle of A-549 cancer cells, indicated by a shift from the predominant Go/G, phase.

Apoptosis Analysis^[1]

Cell Line:	A-549 cells
Concentration:	5 μM
Incubation Time:	24 h
Result:	Increased the percentage of total apoptotic cells by a factor of 13 from 0.51 to 6.68%.

分子量

389.40

Formula

C₂₂H₁₉N₃O₄

CAS 号

2878360-80-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.