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Caldaret
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Caldaret图片
CAS NO:133804-44-1
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品名称
MCC-135
产品介绍
Caldaret 是一种细胞内Ca2+调节剂,通过反向模式抑制Na+/Ca2+交换作用。
生物活性

Caldaret is an intracellularCa2+handling modulator that acts through reverse modeNa+/Ca2+exchangerinhibition.

IC50& Target

Na+/Ca2+exchanger[1]

体外研究
(In Vitro)

Caldaret (MCC-135) is demonstrated to restore Ca2+-ATPase activity of the sarcoplasmic reticulum (SR) isolated from the myocardium acutely exposed to ischemia and reperfusion in vitro[2].

体内研究
(In Vivo)

Caldaret, an intracellular Ca2+handling modulator, limits infarct size of reperfused canine heart. The cardioprotective effect of Caldaret, a novel intracellular Ca2+handling modulator that acts through reverse-mode Na+/Ca2+exchanger inhibition and potential sarcoplasmic reticulum (SR) Ca2+uptake enhancement, against reperfusion injury is investigated. Intravenously infused Caldaret (3 or 30 microg/kg per hour) for 30 min at left circumflex (LCX)-reperfusion markedly reduces infarct size (by 51.3% or 71.9%, respectively). The amelioration of intracellular Ca2+handling dysfunction achieved by Caldaret leads to cardioprotective effects against reperfusion injury following prolonged ischemia[1]. Caldaret (MCC-135) is a new potent compound with beneficial effects in heart failure. In diabetic rats, Caldaret decreases TR80 significantly without significant effect on developed tension (DT). Caldaret has minimal effects on SR Ca2+uptake in normal rats, that is observed as increased SR Ca2+uptake at uptake time of 20 and 30 s at the highest concentration of 10 μM. In diabetic rats, Caldaret increases SR Ca2+uptake all over the range of uptake time. Both initial rate of SR Ca2+uptake and the amount of Ca2+accumulated in the SR with longer uptake time are increased by Caldaret[2].

Clinical Trial
分子量

256.32

Formula

C11H16N2O3S

CAS 号

133804-44-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro: 

DMSO : 4.81 mg/mL(18.77 mM;ultrasonic and warming and adjust pH to 3 with HCl and heat to 60℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.9014 mL19.5069 mL39.0137 mL
5 mM0.7803 mL3.9014 mL7.8027 mL
10 mM0.3901 mL1.9507 mL3.9014 mL