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Zoniporide hydrochloride hydrate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Zoniporide hydrochloride hydrate图片
CAS NO:863406-85-3
包装与价格：
包装价格(元)
10 mM * 1 mL in DMSO电议
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
CP-597396 hydrochloride hydrate
产品介绍
Zoniporide (CP-597396) hydrochloride hydrate 是 1 型钠氢交换剂(NHE-1)的有效和选择性抑制剂。Zoniporide hydrochloride hydrate 抑制人 NHE-1 (IC50=14 nM)，与其他 NHE 亚型相比具有大于 150 倍的选择性，并有效抑制离体 NHE-1 依赖性的人血小板溶胀 (IC50=59 nM)。
生物活性

Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor ofsodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC50=59 nM)[1][2].

IC50& Target

IC50: 14 nM (NHE-1)[1]

体内研究
(In Vivo)

Zoniporide hydrochloride hydrate (0.25-4 mg/kg; i.v.; every hour for 2 hours) elicits a dose-dependent reduction in infarct size (ED50=0.45 mg/kg/h) in open chest anesthetized rabbits[1].
Zoniporide exhibits moderate plasma protein binding, has a t1/2of 1.5 hours in monkeys, and has one major active metabolite[1].
Zoniporide hydrochloride hydrate treatment shows the AUC0-∞and t1/2are 0.07 μg h/mL and 0.5 hours, respectively[2].

Animal Model:Rabbit[1]
Dosage:0.25, 1, 4 mg/kg
Administration:Every hour for 2 hours; intravenous injection
Result:Elicited a significant dose-dependent reduction in infarct size in the anesthetized rabbit. The ED50was 0.45 mg/kg/h.
Animal Model:Rat[2]
Dosage:1 mg/kg
Administration:Intravenous injection(Pharmacokinetic Analysis)
Result:The AUC0-∞and t1/2were 0.07 μg h/mL and 0.5 hours, respectively.
分子量

374.82

性状

Solid

Formula

C17H19ClN6O2

CAS 号

863406-85-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 2 mg/mL(5.34 mM;Need ultrasonic and warming)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.6679 mL13.3397 mL26.6795 mL
5 mM0.5336 mL2.6679 mL5.3359 mL
10 mM---------
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。