TP-020

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TP-020

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1800025-30-2

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品名称

MGAT2-IN-1

产品介绍

TP-020 (MGAT2-IN-1) 是一种可口服的单酰甘油酰基转移酶 (MGAT2) 抑制剂，对人和小鼠 MGAT2 的IC₅₀值分别为 7.8 和 2.4 nM。

生物活性

TP-020 (MGAT2-IN-1) is an orally active inhibitor of monoacylglycerolacyltransferase(MGAT2) withIC₅₀of 7.8 and 2.4 nM for human and mouseMGAT2, respectively.

IC₅₀& Target

IC50: 7.8 nM (Human MGAT2), 2.4 nM (Mouse MGAT2)^[1]

体内研究
(In Vivo)

TP-020 (3, 10 mg/kg, p.o.) dose-dependently suppresses plasma TG elevation, and plasma CM/TG AUC in mice. TP-020 does not decrease MG absorption but inhibits MGAT2-dependent TG/DG resynthesis. In the lipid utilization analysis, TP-020 significantly increases free fatty acid (FFA) and acylcarnitine levels. TP-020 (30 mg/kg) also significantly reduces food intake dose dependently, suppresses BW gains. TP-020 shows anti-diabetic effects in mice^[1].

分子量

654.01

性状

Solid

Formula

C₂₇H₂₁ClF₅N₇O₃S

CAS 号

1800025-30-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 125 mg/mL(191.13 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.5290 mL	7.6451 mL	15.2903 mL
5 mM	0.3058 mL	1.5290 mL	3.0581 mL
10 mM	0.1529 mL	0.7645 mL	1.5290 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。