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1,4-dideoxy-1,4-imino-D-Arabinitol(hydrochloride)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
1,4-dideoxy-1,4-imino-D-Arabinitol(hydrochloride)图片
CAS NO:100991-92-2
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Cas No.100991-92-2
别名DAB
化学名2R-(hydroxymethyl)-3R,4R-pyrrolidinediol, monohydrochloride
Canonical SMILESOC[C@H]1NC[C@@H](O)[C@@H]1O.Cl
分子式C5H11NO3•HCl
分子量169.6
溶解度10 mg/ml in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

1,4-dideoxy-1,4-imino-D-Arabinitol (DAB) is an inhibitor of glycogen phosphorylase, a key enzyme in glycogenolysis. It inhibits glycogenolysis in isolated liver cells (IC50 = 1.0 μM) and in homogenates of cerebral cortex and cerebellum (IC50s = 463 and 383 nM, respectively).[1][2][3] DAB is used to inhibit glycogenolysis, in liver and in brain, in various animal models.[4][5][6]

Reference:
[1]. Andersen, B., and Westergaard, N. The effect of glucose on the potency of two distinct glycogen phosphorylase inhibitors. Biochem. J. 367(Pt. 2), 443-450 (2002).
[2]. Andersen, B., Rassov, A., Westergaard, N., et al. Inhibition of glycogenolysis in primary rat hepatocytes by 1, 4-dideoxy-1,4-imino-D-arabinitol. Biochem. J. 342, 545-550 (1999).
[3]. Walls, A.B., Sickmann, H.M., Brown, A., et al. Characterization of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) as an inhibitor of brain glycogen shunt activity. J. Neurochem. 105(4), 1462-1470 (2008).
[4]. Fosgerau, K., Westergaard, N., Quistorff, B., et al. Kinetic and functional characterization of 1,4-dideoxy-1, 4-imino-d-arabinitol: a potent inhibitor of glycogen phosphorylase with anti-hyperglyceamic effect in ob/ob mice. Arch. Biochem. Biophys. 380(2), 274-284 (2000).
[5]. Gibbs, M.E. Role of Glycogenolysis in Memory and Learning: Regulation by Noradrenaline, Serotonin and ATP. Front. Integr. Neurosci. 9:70, 70 (2016).
[6]. Marina, N., Ang, R., Machhada, A., et al. Brainstem hypoxia contributes to the development of hypertension in the spontaneously hypertensive rat. Hypertension 65(4), 775-783 (2015).