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(±)14(15)-EET-SI
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(±)14(15)-EET-SI图片
CAS NO:218461-97-3
包装与价格：
包装价格(元)
25μg电议
50μg电议
100μg电议

产品介绍
Cas No.218461-97-3
Canonical SMILESCCCCC[C@H]1O[C@H]1C/C=C\C/C=C\C/C=C\CCCC(=O)NS(=O)(=O)C
分子式C21H35NO4S
分子量397.6
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml,Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes. The EETs are released in response to acetylcholine, bradykinin, arachidonic acid, or cyclic stretch. (±)14(15)-EET-SI is the methyl sulfonamide analog of 14(15)-EET. This substitution results in a metabolically more stable compound because it is not sensitive to β-oxidation or membrane esterification. (±)14(15)-EET-SI is equipotent to 14(15)-EET in vascular agonist activity as measured by relaxation of precontracted bovine coronary arteries. In addition, 14(15)-EET and the methyl sulfonamide analog both stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells.