Alamandine

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Alamandine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1176306-10-7

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议

产品介绍

Alamandine 是一种血管活性肽，是肾素-血管紧张素系统 (RAS) 的成员，还是一种 G 蛋白偶联受体 MrgD 的内源性配体。Alamandine 可通过抗高血压作用来保护肾脏和心脏。

生物活性

Alamandine, a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions^[1]^[2].

体外研究
(In Vitro)

Alamandine is generated by catalysis of Ang A via ACE2 or directly from Angiotensin 1-7 (Ang-(1-7)). Derived from angiotensin II (Ang II) by Ang II-converting enzyme 2 (ACE2), it shows vasodilating (thus protective) properties. Ang (1-7) can be decarboxylated to a peptide called Alamandine. Alamandine is also an endogenous peptide identified in human blood^[1].
Alamandine elevates cAMP concentration in primary endothelial and mesangial cells, also suggesting Gs coupling^[2].
Alamandine decreases secretion, expression, and blood levels of leptin. Alamandine induced expression of iNOS and plasminogen activator inhibitor-1 (PAI-1) in adipose tissue and isolated adipocytes^[2].

体内研究
(In Vivo)

Alamandine (0.15 μL/h; administered by mini-osmotic pumps; for 6 weeks) treatment ameliorates hypertension and impaires left ventricle (LV) function in SHRs. Also decreases the mass gains of heart and lung in SHRs, suppresses cardiomyocyte cross-sectional area expansion, and inhibits the mRNA levels of atrial natriuretic peptide and brain natriuretic peptide^[3].

Animal Model:	Male spontaneously hypertensive rats (SHRs, 50-week-old)^[3]
Dosage:	0.15 μL/h (~50 μg/kg/day)
Administration:	Administered by mini-osmotic pumps; for 6 weeks
Result:	Attenuated hypertension, alleviated cardiac hypertrophy, and improved LV function.

分子量

855.00

性状

Solid

Formula

C₄₀H₆₂N₁₂O₉

CAS 号

1176306-10-7

Sequence

Ala-Arg-Val-Tyr-Ile-His-Pro

Sequence Shortening

ARVYIHP

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 25 mg/mL(29.24 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.1696 mL	5.8480 mL	11.6959 mL
5 mM	0.2339 mL	1.1696 mL	2.3392 mL
10 mM	0.1170 mL	0.5848 mL	1.1696 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 25 mg/mL (29.24 mM); Clear solution; Need ultrasonic and warming

*以上所有助溶剂都可在本网站选购。