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KIN1400
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KIN1400图片
CAS NO:446826-86-4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Cas No.446826-86-4
Canonical SMILESFC(F)OC(C=C1)=CC=C1C(NC2=NC3=C(C=CC=C3)S2)C4=C(O)C(N=CC=C5)=C5C=C4
分子式C24H17F2N3O2S
分子量449.5
溶解度DMF: 30 mg/mL,DMSO: 30 mg/mL,DMSO:PBS (pH 7.2) (1:2): 0.3 mg/mL,Ethanol: 2 mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

KIN1400 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity. It induces expression of the innate immune genes RIG-1, MDA5, IFIT1, IFIT2, IFITM1, OAS3, and Mx1 in THP-1 cells stimulated with phorbol 12-myristate 13-acetate . KIN1400 (20 μM) reduces West Nile and dengue viral RNA levels in HEK293 and Huh7 cells, respectively. It also inhibits hepatitis C virus (HCV) replication in a concentration-dependent manner in Huh7 cells.