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Cloxacillin(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cloxacillin(sodium salt)图片
CAS NO:642-78-4
包装与价格:
包装价格(元)
5g电议
10g电议
25g电议

产品介绍
Cloxacillin is a semisynthetic β-lactamase inhibitor.
Cas No.642-78-4
别名氯唑西林钠
Canonical SMILESCC1(C)[C@H](C([O-])=O)N2C([C@@H](NC(C3=C(C)ON=C3C4=CC=CC=C4Cl)=O)[C@@]2([H])S1)=O.[Na+]
分子式C19H17ClN3O5S•Na
分子量457.9
溶解度DMF: 20 mg/ml,DMSO: 16 mg/mL,Ethanol: 2 mg/mL,PBS (pH 7.2): 10 mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cloxacillin is a semisynthetic β-lactamase inhibitor. It binds to and inactivates penicillin-binding proteins that cross-link peptidoglycans, which are structural components of bacterial cell walls. In vitro, addition of cloxacillin (0.50 μg/ml) almost completely inhibits B. megaterium growth. Cloxacillin inhibits recombinant type Ib penicillinase, P. vulgaris cephalosporinase, and C. freundii cephalosporinase (Kis = 15, 0.27, and 0.027 μM, respectively) as well as S. aureus and S. epidermidis growth (MICs = 0.2 and 0.2 μg/ml, respectively). In vitro, addition of cloxacillin (0.50 μg/ml) almost completely inhibits B. megaterium growth. Formulations containing cloxacillin have been used to treat infections caused by methicillin-sensitive staphylococci.