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cis-Resveratrol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
cis-Resveratrol图片
CAS NO:61434-67-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
cis-Resveratrol 具有显着的抗病毒活性。
Cas No.61434-67-1
别名顺式白藜芦醇
化学名5[(1Z)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol
Canonical SMILESOC1=CC(/C=C\C2=CC=C(O)C=C2)=CC(O)=C1
分子式C14H12O3
分子量228.2
溶解度50mg/mL in DMSO, or in DMF
储存条件Store at -80℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Resveratrol is a potent phenolic antioxidant found in grapes, red wine, and various berries that also has antiproliferative and anti-inflammatory activity. cis-Resveratrol is the double bond isomer of trans-resveratrol, the more often studied and naturally abundant of the two resveratrol isomers. cis-Resveratrol exhibits antioxidant activity in the &#181M range similar to that observed with trans-resveratrol. It blocks production of reactive oxygen species (ROS) by inhibition of NAD(P)H oxidase and also inhibits production of nitric oxide. At a concentration of 100 &#181M, cis-resveratrol significantly inhibits the expression of genes related to the Rel/NF-κB/IκB family, adhesion molecules, and acute-phase proteins in LPS and INF-γ-stimulated murine peritoneal macrophages. cis-Resveratrol inhibits uptake of noradrenaline and 5-HT by synaptosomes from rat brain with IC50 values of 79 and 51 &#181M, respectively. It also inhibits human monoamine oxidase-A (MOA-A) and MOA-B with IC50 values of 25 and 61 &#181M, respectively, which is similar to, but slightly less effective than, values obtained with trans-resveratrol.

Reference:
[1]. Rotondo, S., Rajtar, G., Manarini, S., et al. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. British Journal of Pharmacology 123, 1691-1699 (1998).
[2]. Orallo, F. Comparative studies of the antioxidant effects of cis- and trans-resveratrol. Current Medicinal Chemistry 13, 87-98 (2006).
[3]. Leiro, J., Arranz, J.A., Fraiz, N., et al. Effect of cis-resveratrol on genes involved in nuclear factor kappa B signaling. International Immunopharmacology 5, 393-406 (2005).
[4]. Yánez, M., Fraiz, N., Cano, E., et al. Inhibitory effects of cis- and trans-resveratrol on noradrenaline and 5-hydroxytryptamine uptake and on monoamine oxidase activity. Biochemical and Biophysical Research Communications 344, 688-695 (2006).