LP-922761 is a potent, selective and orally activeadapter protein-2 associated kinase 1 (AAK1) inhibitor withIC₅₀s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 also inhibitsBMP-2-inducible protein kinase (BIKE)with anIC₅₀of 24 nM. LP-922761 exhibits no significant activity atcyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors^[1].

IC50: 4.8 nM (Adapter protein-2 associated kinase 1 (AAK1) in enzyme assays); 7.6 nM (AAK1 in cell assays); 24 nM (BMP-2-inducible protein kinase (BIKE))^[1]

In mouse, LP-922761 has a brain to plasma ratio of 0.007, indicating that LP-922761 is essentially restricted to the peripheral compartment^[1].

410.47

Solid

C₂₁H₂₆N₆O₃

1454808-95-7

Room temperature in continental US; may vary elsewhere.

DMSO : 41.67 mg/mL(101.52 mM;ultrasonic and warming and heat to 80℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。