| 包装: | 5mg |
| 市场价: | 1600元 |
| 生物活性 | LP-922761 hydrate is a potent, selective and orally activeadapter protein-2 associated kinase 1 (AAK1) inhibitor withIC50s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 hydrate also inhibitsBMP-2-inducible protein kinase (BIKE)with anIC50of 24 nM. LP-922761 hydrate shows less activity atcyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors[1]. | |||||||||
| IC50& Target | IC50: 4.8 nM (Adapter protein-2 associated kinase 1 (AAK1) in enzyme assays); 7.6 nM (AAK1 in cell assays); 24 nM (BMP-2-inducible protein kinase (BIKE))[1] | |||||||||
| 体内研究 (In Vivo) | In mouse, LP-922761 has a brain to plasma ratio of 0.007, indicating that LP-922761 is essentially restricted to the peripheral compartment[1]. | |||||||||
| 分子量 | 414.98 | |||||||||
| 性状 | Solid | |||||||||
| Formula | C21H26N6O3.1/4H2O | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 |
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