AAK1-IN-3, a quinoline analogue, is a brain-penetrantadaptor protein 2-associated kinase 1 (AAK1)inhibitor with anIC₅₀ of 11 nM. AAK1-IN-3 has the potential for neuropathic pain research^[1].

AAK1-IN-3 (compound (R)-31) is brain-penetrant kinase inhibitors with a B/P ratio of 1.3^[1].
AAK1-IN-3 inhibits AAK1 in HEK293 cells (IC50=108 nM)^[1].

AAK1-IN-3 (compound (R)-31; 30 mg/kg; sc; signle dose) causes a 46% reduction of μ2 phosphorylation in C57BL6 mice^[1].

316.40

C₂₀H₂₀N₄

1802703-20-3

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