CAS NO: | 58749-23-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | Licochalcone B is an extract from the root ofGlycyrrhiza uralensis. Licochalcone B inhibitsamyloid β(42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42fibrils, reduce metal-induced Aβ42aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation ofNF-κBp65 in LPS signaling pathway. Licochalcone B inhibits growth and inducesapoptosisof NSCLC cells. Licochalcone B specifically inhibits theNLRP3inflammasome by disrupting NEK7‐NLRP3 interaction[1][2][3][4]. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | Licochalcone B (IC50: 2.16 μM) 抑制 Aβ42 聚集并分解 Aβ42 预先形成的原纤维[1]。 Western Blot Analysis[2]
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体内研究 (In Vivo) | Licochalcone B (1-25 mg/kg,口服灌胃) 减轻由 CCl4[5]诱导的小鼠肝毒性及氧化应激。
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分子量 | 286.28 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C16H14O5 | ||||||||||||||||
CAS 号 | 58749-23-8 | ||||||||||||||||
中文名称 | 甘草查尔酮 B | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 83.33 mg/mL(291.08 mM;Need ultrasonic) H2O :< 0.1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble) 配制储备液
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以下溶剂前显示的百
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