CAS NO: | 57265-65-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | Calmidazolium chloride (R 24571) is acalmodulin(CaMK)antagonist, antagonizing CaM-dependentphosphodiesteraseand calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase withIC50s of 0.15 and 0.35 μM, respectively[1]. Also in anti-cancer research[2]. Calmidazolium binds toCaMKwith aKdof 3 nM. | ||||||||||||||||
IC50& Target | Kd: 3 nM (Calmodulin)[3] | ||||||||||||||||
体外研究 (In Vitro) | Calmidazolium chloride is widely used as a calmodulin (CaM) antagonist, but is also known to induce apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits growth of mouse F9 ECCs[2]. Cell Viability Assay[2]
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分子量 | 687.70 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C31H23Cl7N2O | ||||||||||||||||
CAS 号 | 57265-65-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 100 mg/mL(145.41 mM;Need ultrasonic) 配制储备液
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