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Tacrine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tacrine hydrochloride图片
CAS NO:1684-40-8
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
100mg电议
200mg电议
500mg电议

产品名称
盐酸他克林
产品介绍
Tacrine hydrochloride 是一种AChEBChE的有效抑制剂,IC50值分别为 31 nM 和 25.6 nM 。Tacrine hydrochloride 也是NMDAR的抑制剂,IC50值为 26 μM。Tacrine hydrochloride 可用于研究阿尔茨海默氏症。
生物活性

Tacrine hydrochloride is a potent inhibitor of bothAChEandBChE, withIC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also aNMDARinhibitor, with anIC50of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease[1][2].

IC50& Target

IC50: 31 nM (AChE), 25.6 nM (BChE), 26 μM (NMDAR)[1][2]

体外研究
(In Vitro)

Tacrine (12.5-37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner[1].
Tacrine reduces the neurotoxicity induced by the activation of the NMDARs in murine cortical neuronal cultures with an IC50of ~500 μM[2].
Tacrine inhibits the NMDAR responses in a concentration-dependent manner with an IC50of ~190 μM at -60 mV[2].

体内研究
(In Vivo)

Tacrine (20-40 μmol/kg; s.c.) disrupts retention of learning in 17- and 30-day old mice in passive avoidance, and while the low dose of tacrine treatment (5 μmol/kg; s.c.) improves retention in 17-day old mice[2].
Tacrine (0.1-0.4 mg/mL; i.p. for 7 d) inhibits the expression of AChE, but does not significantly improve the protection of the retina function and morphology in mice[3].

Clinical Trial
分子量

234.72

性状

Solid

Formula

C13H15ClN2

CAS 号

1684-40-8

中文名称

盐酸他克林;四氢氨基吖啶

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
In Vitro: 

H2O : 33.33 mg/mL(142.00 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM4.2604 mL21.3020 mL42.6040 mL
5 mM0.8521 mL4.2604 mL8.5208 mL
10 mM0.4260 mL2.1302 mL4.2604 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (stored under nitrogen)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 16.67 mg/mL (71.02 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。