CAS NO: | 1684-40-8 |
包装 | 价格(元) |
10 mM * 1 mL in Water | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Tacrine hydrochloride is a potent inhibitor of bothAChEandBChE, withIC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also aNMDARinhibitor, with anIC50of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease[1][2]. | ||||||||||||||||
IC50& Target | IC50: 31 nM (AChE), 25.6 nM (BChE), 26 μM (NMDAR)[1][2] | ||||||||||||||||
体外研究 (In Vitro) | Tacrine (12.5-37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner[1]. | ||||||||||||||||
体内研究 (In Vivo) | Tacrine (20-40 μmol/kg; s.c.) disrupts retention of learning in 17- and 30-day old mice in passive avoidance, and while the low dose of tacrine treatment (5 μmol/kg; s.c.) improves retention in 17-day old mice[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 234.72 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C13H15ClN2 | ||||||||||||||||
CAS 号 | 1684-40-8 | ||||||||||||||||
中文名称 | 盐酸他克林;四氢氨基吖啶 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 33.33 mg/mL(142.00 mM;Need ultrasonic) 配制储备液
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