CAS NO: | 41059-79-4 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Timosaponin AIII could inhibit acetylcholinesterase(AChE)activity, with anIC50of 35.4 μM. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC50of 35.4 μM[1]. Timosaponin AIII is identified as a major selective cytotoxic activity in BN108, and its selective cytotoxic activity involves inhibition of mTOR, induction of ER stress and protective autophagy[2]. | ||||||||||||||||
体内研究 (In Vivo) | Of the tested steroidal saponins, Timosaponin AIII (TA3) most potently improves memory deficits. Timosaponin AIII increases the scopolamine-induced reduction in step-through latency by 17% (10 mg/kg), 28% (20 mg/kg), and 43% (40 mg/kg). During the acquisition trial, no differences in latent time are observed. Timosaponin AIII (20, 40 mg/kg, p.o.) potently inhibits this reduction of acetylcholine in scopolamine-treated mouse brain. The inhibitory effect of Timosaponin AIII is comparable to that of tacrine, which is used as a positive control[1]. | ||||||||||||||||
分子量 | 740.92 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C39H64O13 | ||||||||||||||||
CAS 号 | 41059-79-4 | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 125 mg/mL(168.71 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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