CAS NO: | 1233855-46-3 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) withIC50values of 50 to 70mg/kg in various rat brain regions. | ||||||||||||||||
IC50& Target | IC50: 50-70mg/kg (FAAH, rat brain regions)[1] | ||||||||||||||||
体外研究 (In Vitro) | ExVivo: BIA 10-2474 proves to be a potent FAAH inhibitor with IC50s of 50-70mg/kg (i.p.) in various brain regions. IC50values for brain regions are 52 (cerebellum), 67 (rest of brain), 68 (cortex), and 71 mg/kg (hypothalamus)[1]. | ||||||||||||||||
体内研究 (In Vivo) | In January 2016, severe adverse events (SAE) occurs in the Phase I clinical trial using the drug BIA 10-2474 including one death. The possibilities for failure of trials such as off-target effect, dose calculation, unexpected immune response, species variation, and cumulative dose toxicity would be sought[2]. | ||||||||||||||||
分子量 | 300.36 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C16H20N4O2 | ||||||||||||||||
CAS 号 | 1233855-46-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 2.2 mg/mL(7.32 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |