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BIA 10-2474
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BIA 10-2474图片
CAS NO:1233855-46-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
BIA 10-2474是脂肪酸酰胺水解酶FAAH的抑制剂,对大鼠大脑不同区域的IC50值为50至70mg/kg。
生物活性

BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) withIC50values of 50 to 70mg/kg in various rat brain regions.

IC50& Target

IC50: 50-70mg/kg (FAAH, rat brain regions)[1]

体外研究
(In Vitro)

ExVivo: BIA 10-2474 proves to be a potent FAAH inhibitor with IC50s of 50-70mg/kg (i.p.) in various brain regions. IC50values for brain regions are 52 (cerebellum), 67 (rest of brain), 68 (cortex), and 71 mg/kg (hypothalamus)[1].

体内研究
(In Vivo)

In January 2016, severe adverse events (SAE) occurs in the Phase I clinical trial using the drug BIA 10-2474 including one death. The possibilities for failure of trials such as off-target effect, dose calculation, unexpected immune response, species variation, and cumulative dose toxicity would be sought[2].

分子量

300.36

性状

Solid

Formula

C16H20N4O2

CAS 号

1233855-46-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 2.2 mg/mL(7.32 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.3293 mL16.6467 mL33.2934 mL
5 mM0.6659 mL3.3293 mL6.6587 mL
10 mM---------
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。