CAS NO: | 1371591-51-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Firuglipel (DS-8500a) is an orally available, potent and selectiveGPR119agonist. | ||||||||||||||||
IC50& Target | GPR119[1] | ||||||||||||||||
体外研究 (In Vitro) | Firuglipel (DS-8500a) increases intracellular cAMP in a concentration-dependent manner in human, rat, and mouse GPR119-expressing Chinese hamster ovary (CHO)-K1 cells, with EC50values of 51.5, 98.4, and 108.1 nM, respectively. DS-8500a has no effect on intracellular cAMP in pcDNA3.1/CHO-K1 cells[1]. | ||||||||||||||||
体内研究 (In Vivo) | Firuglipel (DS-8500a) (1-30 mg/kg) upregulates glucagon-like peptide-1 and enhances glucose-dependent insulin secretion and improves glucose homeostasis in type 2 diabetic rats[1]. | ||||||||||||||||
分子量 | 467.49 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C25H26FN3O5 | ||||||||||||||||
CAS 号 | 1371591-51-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(213.91 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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