CAS NO: | 2230273-76-2 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Safimaltib (JNJ-67856633) is an orally active, first-in-class, potent, selective and allostericMALT1proteaseinhibitor. Safimaltib in some cases lead to tumor stasis[1][2][3]. | ||||||||||||||||
IC50& Target | MALT1 protease[1][2][3] | ||||||||||||||||
体外研究 (In Vitro) | Safimaltib (JNJ-67856633) is effective and highly bioavailable in both mouse and rat tumors, and in some cases led to tumor stasis. | ||||||||||||||||
体内研究 (In Vivo) | Dose dependent inhibition of the generation of Tregs (CD4+CD25+FoxP3+) following CD3/28 stimulation was observed upon treatment with JNJ-67856633 suggesting a potential immune modulatory role of MALT1 inhibition[3]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 467.32 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C20H11F6N5O2 | ||||||||||||||||
CAS 号 | 2230273-76-2 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 125 mg/mL(267.48 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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