CAS NO: | 5108-96-3 |
包装 | 价格(元) |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate) is a selective and blood-brain barrier (BBB) permeableNF-κBinhibitor. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Pretreatment of cells with Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate; 3-1000 μM) dose-dependently attenuate IL-8 production[1]. | ||||||||||||||||
体内研究 (In Vivo) | The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 164.29 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C5H12N2S2 | ||||||||||||||||
CAS 号 | 5108-96-3 | ||||||||||||||||
中文名称 | 吡咯烷二硫代甲酸铵盐;四亚甲基二硫代氨基甲酸铵;1-吡咯烷二硫代羧酸铵盐;吡咯烷二硫代氨基甲酸铵;1-吡咯烷硫代羧酸铵盐;吡咯二硫代甲酸铵;四次甲基二硫代氨基甲酸铵;1-吡咯烷羰基二硫酸铵盐 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 50 mg/mL(304.34 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
*以上所有助溶剂都可在本网站选购。 |