CAS NO: | 1643958-89-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selectivePDK1inhibitor with aKdof 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 byPDK1[1]. | ||||||||||||||||
IC50& Target | Kd: 9 μM (PDK1)[1] | ||||||||||||||||
体外研究 (In Vitro) | PDK1-IN-RS2 stimulates the catalytic activity of PDK1 toward a peptide substrate by sixfold. The sulfonyl group of PDK1-IN-RS2 interacts with Arg131 through a salt bridge, because the sulfonamide is likely ionized under the crystallization conditions[1]. | ||||||||||||||||
分子量 | 380.89 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C15H9ClN2O2S3 | ||||||||||||||||
CAS 号 | 1643958-89-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
| ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 125 mg/mL(328.18 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |