MOMIPP

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MOMIPP

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1363421-46-8

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议

产品介绍

MOMIPP，一种巨胞饮作用的诱导剂，是一种PIKfyve抑制剂。MOMIPP 可穿过血脑屏障 (BBB)。

生物活性

MOMIPP, a macropinocytosis inducer, is aPIKfyveinhibitor. MOMIPP penetrates the blood-brain barrier (BBB)^[1]^[2].

体外研究
(In Vitro)

MOMIPP can induce intense macropinocytosis, leading to methuosis in cultured glioblastoma cells at low micromolar concentrations^[1].
In U373 and Hs683 cell lines, 3 μM for MOMIPP induces cell vacuolization^[1].
MOMIPP (10 μM) causes early disruptions of glucose uptake and glycolytic metabolism. MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL^[2].

Western Blot Analysis^[2]

Cell Line:	U251 cells
Concentration:	10 μM
Incubation Time:	4 h or 24 h
Result:	Activated the JNK stress kinase pathway.

体内研究
(In Vivo)

MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts^[2].

Animal Model:	Athymic CrTac:NCR-Foxn1mice (female, 7-8 weeks)^[2]
Dosage:	80 mg/kg
Administration:	i.p.; once daily; for 15 consecutive days
Result:	Suppressed progression of intracerebral glioblastoma xenografts.

分子量

292.33

性状

Solid

Formula

C₁₈H₁₆N₂O₂

CAS 号

1363421-46-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 31.25 mg/mL(106.90 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.4208 mL	17.1040 mL	34.2079 mL
5 mM	0.6842 mL	3.4208 mL	6.8416 mL
10 mM	0.3421 mL	1.7104 mL	3.4208 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。