BpV(HOpic)

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BpV(HOpic)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

722494-26-0

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议

产品介绍

BpV(HOpic) 是一种有效的和选择性的PTEN抑制剂，IC₅₀值为 14 nM。Nanocarrier-BpV(HOpic) 具有神经保护作用。

生物活性

BpV(HOpic) is a potent and selective inhibitor ofPTENwith anIC₅₀of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity^[1]^[2].

IC₅₀& Target

IC50: 14 nM (PTEN)^[1]

体外研究
(In Vitro)

BpV(HOpic) (1 μM) treatment increases cell proliferation and decreases apoptotic rate in MG63 cells received Cisplatin treatment^[3].
Bpv(HOpic) (1 μM) enhances migration of C2C12 myoblasts and is associated with activation of PI3K/AKT and MAPK/ERK signalling pathways^[4].
BpV(HOpic) (1 μM; 48 hours) promotes the initiation of swine follicle growth and development, similar as in rodent species and humans^[5].
Nanocarrier-BpV(HOpic) enhances axonal outgrowth of neurons^[2].

体内研究
(In Vivo)

BpV(HOpic) (0.05 mg/kg; i.p.) at reperfusion ameliorates liver ischemia/reperfusion (I/R) injury in vivo^[6].
BpV(HOpic) (200 μg/kg; i.p.) exacerbates renal dysfunction and promotes tubular damage in mice with ischemia/reperfusion injury (IRI)^[7].

Animal Model:	Male Wistar rats are subjected to partial hepatic ischemia^[6]
Dosage:	0.05 mg/kg
Administration:	I.p. injections at the start of reperfusion
Result:	Ameliorated reoxygenation injury and reproduced the hepatoprotective effects obtained by adenosine A2A receptor stimulation.

Animal Model:	Male C57BL/6 mice (8-12 weeks old; 20-30 g ) are subjected to renal ischemia^[7]
Dosage:	200 μg/kg
Administration:	I.p. injections 1 h before ischemia and then administers every 6 h after ischemia for 24 hr
Result:	Raised the level of serum creatinine and blood serum urea nitrogen.

分子量

347.24

性状

Solid

Formula

C₆H₄K₂NO₈V

CAS 号

722494-26-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据

In Vitro:

H₂O : 50 mg/mL(143.99 mM;ultrasonic and warming and heat to 60℃)

DMSO : 2.89 mg/mL(8.32 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.8799 mL	14.3993 mL	28.7985 mL
5 mM	0.5760 mL	2.8799 mL	5.7597 mL
10 mM	0.2880 mL	1.4399 mL	2.8799 mL

请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。