TSPO ligand-1 is the ligand ofAUTAC4(HY-134640) that can be used in the synthesis ofPROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrialautophagyto promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport ofcholesterolfrom the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration^[1][2].

TSPO ligand-1 gene is induced to increase expression in the context of selective activation of neurons in male C57Bl6/N mice. Moreover, neuronal activation under physiological and psychopharmacological conditions also results in increased TSPO levels in adult mice^[2].
TSPO ligand-1 can serve as the sole marker of glial cell activity in Alzheimer’s disease thus tracking the formation of different neural cells^[3].
TSPO ligand-1 can regulate mitochondrial fatty acid oxidation (FAO) and thus effects mitochondrial energy homeostasis in MA-10 Leydig cell line^[4].

283.71

C₁₆H₁₀ClNO₂

4560-08-1

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