包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite ofAbemaciclib(HY-16297A), is aCDKinhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to designPROTACCDK4/6degrader[1][2]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Abemaciclib metabolite M18 hydrochloride exhibits T1/2of 43.1 hr in plasma in healthy subjects[3]. | ||||||||||||||||
体内研究 (In Vivo) | CDK4/6 inhibitors results T-cell persistence and immunologic memory increasing in mice receiving tumor-specific CD8+T cells[5]. | ||||||||||||||||
分子量 | 531.00 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C25H29ClF2N8O | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 125 mg/mL(235.40 mM;Need ultrasonic) H2O : 100 mg/mL(188.32 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
*以上所有助溶剂都可在本网站选购。 |