BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand forPD-1/PD-L1immune checkpoint, and aPROTAClinker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PROTACPD-1/PD-L1degrader-1 (HY-131183). PROTACPD-1/PD-L1degrader-1 inhibitsPD-1/PD-L1interaction with an IC₅₀of 39.2 nM^[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

780.18

Solid

C₄₁H₄₅Cl₃N₄O₅

2691796-83-3

Room temperature in continental US; may vary elsewhere.