CAS NO: | 923288-95-3 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Nilotinib (AMN107) hydrochloride is an orally activeBcr-Abltyrosine kinase inhibitor with antineoplastic activity and can be used in studies of chronic myelogenous leukaemia[1][2][3]. | ||||||||
体外研究 (In Vitro) | Nilotinib hydrochloride, selective Abl inhibitor, is designed to interact with the ATP-binding site of BCR-ABL with a higher affinity than imatinib while being significantly more potent compared with imatinib (IC50<30 nm), also maintains activity against most of the bcr-abl point mutants that confer imatinib resistance[1]. | ||||||||
体内研究 (In Vivo) | Nilotinib hydrochloride (oral gavage, 40 mg/kg, daily, 4 weeks) shows equivalent or higher antitumor effects in BALB/cSLc-nu/nu mice with GIST xenograft[2].
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Clinical Trial | |||||||||
分子量 | 565.98 | ||||||||
Formula | C28H23ClF3N7O | ||||||||
CAS 号 | 923288-95-3 | ||||||||
中文名称 | 盐酸尼洛替尼;盐酸尼罗替尼 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |