CAS NO: | 2089381-40-6 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | CHMFL-EGFR-202 is a potent, irreversible inhibitor ofepidermal growth factor receptor (EGFR) mutant kinase, withIC50s of 5.3 nM and 8.3 nM for drug-resistant mutantEGFRT790M and WTEGFRkinases, respectively. CHMFL-EGFR-202 exhibits ~10-fold selectivity forEGFRL858R/T790M against theEGFRwild-type in cells. CHMFL-EGFR-202 adopts a covalent “DFG-in-C-helix-out” inactive binding conformation withEGFR, with strong antiproliferative effects againstEGFRmutant-driven nonsmall-cell lungcancer(NSCLC) cell lines[1]. | ||||||||
IC50& Target |
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体外研究 (In Vitro) | CHMFL-EGFR-202 potently inhibits EGFR primary mutants (L858R, del19) and drug-resistant mutant L858R/T790M[1]. | ||||||||
分子量 | 489.96 | ||||||||
Formula | C25H24ClN7O2 | ||||||||
CAS 号 | 2089381-40-6 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |