DDR1-IN-5 is a selectiveDiscoidin Domain Receptorfamily, member 1 (DDR1)inhibitor with anIC₅₀of 7.36 nM. DDR1-IN-5 inhibits auto-phosphorylation DDR1b (Y513) with anIC₅₀of 4.1 nM. DDR1-IN-5 has anti-cancer activity^[1].

DDR1-IN-5 (compound 121; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC₅₀=62 nM)^[1].
DDR1-IN-5 (72 hours) has cytotoxicity in LX-2 cells (CC₅₀>40 μM)^[1].

434.37

Solid

C₂₂H₁₃F₃N₆O

2416022-90-5

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

DMSO : 2.78 mg/mL(6.40 mM;ultrasonic and warming and heat to 60℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。