N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) 是一种有效的神经氨酸酶（唾液酸酶）抑制剂。
| Cas No. | 24967-27-9 |
| 别名 | N-乙酰-2,3-二脱氢-2-脱氧神经氨酸,Neu5Ac2en; DANA |
| Canonical SMILES | OC(C1=C[C@H](O)[C@@H](NC(C)=O)[C@@]([C@H](O)[C@H](O)CO)([H])O1)=O |
| 分子式 | C11H17NO8 |
| 分子量 | 291.3 |
| 溶解度 | DMF: 0.1 mg/ml,DMSO: 1 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | N-acetyl-2,3-dehydro-2-Deoxyneuraminic acid (DANA) is an inhibitor of human neuriminidases (sialidases) NEU1-4 (IC50s = 143, 43, 61, and 74 μM, respectively). In vivo, DANA (30 μL of a 5 mM solution) reduces latency to first seizure and increases seizure duration in a rat model of potassium-induced seizures. |
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