Vosoritide

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Vosoritide

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1480724-61-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

BMN 111

产品介绍

Vosoritide (BMN 111) 是一种改良的重组 CNP (C 型钠尿肽) 类似物，与NPR-B(B 型钠尿肽受体) 结合并降低FGFR3(成纤维细胞生长因子受体 3) 的活性。Vosoritide 可用于软骨症和侏儒症的研究。

生物活性

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds toNPR-B(natriuretic peptide receptor type B) and reduces the activity ofFGFR3(fibroblast growth factorreceptor 3). Vosoritide can be used in achondroplasia and dwarfism research^[1]^[2]^[3].

体外研究
(In Vitro)

Vosoritide (0.1 μM; 1 h) decreases NPR2 phosphorylation in chondrocytes^[2].
Vosoritide (0.1 μM; 6 d) improves chondrocyte differentiation and increases the proliferative growth plate area of cultured Fgfr3^Y367C/+femurs^[2].
Vosoritide (10 μM; overnight) reduces ERK1/2 activation in ACH growth-plate chondrocytes^[3].

Western Blot Analysis^[2]

Cell Line:	Chondrocyte cultures
Concentration:	0.1 μM
Incubation Time:	1 hour
Result:	Led to reduction in NPR2 phosphorylation.

Western Blot Analysis^[3]

Cell Line:	Chondrocyte
Concentration:	10 μM
Incubation Time:	Overnight
Result:	Prevented FGF-mediated increase in ERK1/2 phosphorylation.

体内研究
(In Vivo)

Vosoritide (subcutaneous injection; 800 μg/kg; once daily; 20 d) treatment leads to improvement in skeletal parameters in Fgfr3 gain-of-function mutation mouse^[3].

Animal Model:	Fgfr3^Y367C/+mice^[3]
Dosage:	800 μg/kg
Administration:	Subcutaneous injection; 800 μg/kg; once daily; 20 days
Result:	Observed phenotypic changes including flattening of the skull, elongation of the snout, improvement of the anterior crossbite, larger paws and digits, and longer and straightened tibias and femurs.

Clinical Trial

分子量

4102.73

Formula

C₁₇₆H₂₉₀N₅₆O₅₁S₃

CAS 号

1480724-61-5

Sequence

Pro-Gly-Gln-Glu-His-Pro-Asn-Ala-Arg-Lys-Tyr-Lys-Gly-Ala-Asn-Lys-Lys-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys (Disulfide bridge:Cys23-Cys39)

Sequence Shortening

PGQEHPNARKYKGANKKGLSKGCFGLKLDRIGSMSGLGC (Disulfide bridge:Cys23-Cys39)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.