CAS NO: | 1243266-04-7 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Tovetumab (MEDI-575) is an anti-PDGFRαmonoclonal antibody that selectively blocks thePDGFRαsignal transduction. Tovetumab can be used in the research of glioblastoma and non-small cell lungcancer(NSCLC)[1][2]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Tovetumab (10-100 nM, 1-2 h) binds to PDGFRα on H1703 cells (determined by Alexa647-labeled tovetumab)[1]. | ||||||||||||||||
体内研究 (In Vivo) | Tovetumab (0.6-60 mg/kg, i.v.) blocks the PDGFRα-mediated elimination of PDGF-AA, leading to an increase in circulating PDGF-AA level in Cynomolgus monkeys[1].
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Clinical Trial | |||||||||||||||||
性状 | Liquid | ||||||||||||||||
CAS 号 | 1243266-04-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |