CAS NO: | 469-59-0 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Jervine (11-Ketocyclopamine) is a potentHedgehog(Hh)inhibitor with anIC50of 500-700 nM[1]. Jervine is a natural teratogenic sterodial alkaloid from rhizomes ofVeratrum nigrum. Jervine has anti-inflammatory and antioxidant properties[2]. | ||||||||||||||||
IC50& Target | IC50: 500-700 nM (Hedgehog)[1] | ||||||||||||||||
体外研究 (In Vitro) | Jervine (40 μM; 6, 12 and 24 hours) inhibits Akt phosphorylation[3]. Western Blot Analysis[1]
| ||||||||||||||||
体内研究 (In Vivo) | Jervine (orally; 50-400 mg/kg) exerts 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema[2].
| ||||||||||||||||
分子量 | 425.60 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C27H39NO3 | ||||||||||||||||
CAS 号 | 469-59-0 | ||||||||||||||||
中文名称 | 蒜黎芦碱;介芬胺 | ||||||||||||||||
结构分类 |
| ||||||||||||||||
来源 |
| ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
| ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 1 mg/mL(2.35 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |