CAS NO: | 334998-36-6 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | CUR61414 is a novel, potent and cell permeableHedgehogsignaling pathway inhibitor(IC50 =100-200 nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds tosmoothened (Smo)with aKi value of 44 nM. CUR-61414 can induceapoptosisincancercells without affecting neighboring non-tumor cells[1][2]. | ||||||||||||||||
IC50& Target | Hedgehog inhibitor[1] | ||||||||||||||||
体外研究 (In Vitro) | CUR61414 is able to arrest proliferation of basal cells within the BCC-like lesions and induce cells to undergo apoptosis resulting in complete regression of the lesions, without affecting neighboring skin cells[1]. | ||||||||||||||||
体内研究 (In Vivo) | CUR61414 cause regression of these lesions in the mice, which are exposed to UV light irradiation for 6-9 months, producing many microscopic BCC-like basaloid lesions throughout their skin. Moreover,a significant increase in apoptotic nuclei can be seen in basaloid nests after CUR61414 treatment and no overt toxicity is observed in the skin surrounding the lesions[1]. | ||||||||||||||||
分子量 | 550.69 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C31H42N4O5 | ||||||||||||||||
CAS 号 | 334998-36-6 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(181.59 mM;Need ultrasonic) 配制储备液
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