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Itraconazole-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Itraconazole-d5图片
CAS NO:1217510-38-7
包装与价格:
包装价格(元)
500 μg电议
1mg电议

产品名称
R51211-d5
产品介绍
Itraconazole-d5 (R51211-d5) 是 Itraconazole 的氘代物。Itraconazole (R51211) 是一种三唑类抗真菌药,也是一种有效的口服活性的Hedgehog信号通路拮抗剂,IC50约为 800 nM。Itraconazole 可有效抑制羊毛甾醇 14α-脱甲基酶 (Cytochrome P450) ,从而抑制羊毛甾醇向麦角固醇的氧化转化。Itraconazole 具有抗癌和抗血管生成作用。
生物活性

Itraconazole-d5 (R51211-d5) is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally activeHedgehog(Hh) signaling pathwayantagonist with anIC50of ~800 nM. Itraconazole potently inhibits lanosterol14α-demethylase(cytochrome P450enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

710.66

Formula

C35H33D5Cl2N8O4

CAS 号

1217510-38-7

中文名称

伊曲康唑 d5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.