您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Lumula
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Lumula
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lumula图片
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Canonical SMILESO[C@@H]1[C@H](C/C=C\CCCC(N([H])CC)=O)[C@@H](CCC(CCCCCCC)=O)[C@H](O)C1
分子式C24H43NO4
分子量409.6
溶解度DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 50 mg/ml,Ethanol:PBS (pH 7.2): miscible
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

There are currently four prostaglandin (PG) derivatives which have been approved for human clinical use for the treatment of glaucoma. The names of the PGs and the concentrations of the approved doses are: travoprost (40 µg/ml), latanoprost (50 µg/ml), bimatoprost (300 µg/ml), and unoprostone (1,500 µg/ml). All of these compounds are modified at C-1 in order to act as lipophilic prodrugs in the eye. All have also been postulated to function via activation of the prostanoid FP receptor. Unoprostone and bimatoprost stand out in this class due to their lack of potency. Both are also claimed to have "alternate" mechanisms of actions: as a "docosanoid" in the case of unoprostone and as a "prostamide" in the case of bimatoprost. Lumula is a hybrid eicosanoid analog which incorporates the "docosanoid" features of unoprostone as well as the "prostamide" features of bimatoprost. Based on classical structure-activity relationships which have been established for prostanoid receptors, one would predict very low activity for lumula. The N-ethyl amide prodrug moiety which it inherits from bimatoprost is slow to hydrolyze, and the lower side chain modifications inherited from unoprostone interfere with FP receptor binding. Lumula is therefore a good tool for testing the validity of the alternate mechanism theories.