您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > YO-01027
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
YO-01027
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
YO-01027图片
CAS NO:209984-56-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Dibenzazepine
DBZ
产品介绍
YO-01027 (Dibenzazepine) (GMP) 是 GMP 级别的 YO-01027 (HY-13526)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。YO-01027 是一种有效的 γ-分泌酶抑制剂。
生物活性

YO-01027 (Dibenzazepine) (GMP) isYO-01027(HY-13526) produced by using GMP guidelines.GMP small moleculeswork appropriately as an auxiliary reagent for cell therapy manufacture. YO-01027 is a potentγ-secretaseinhibitor[1][2].

IC50& Target

IC50: 2.92±0.22 (Notch), 2.64±0.30 (APPL) nM[1]

体外研究
(In Vitro)

YO-01027 (0.25-10 μM, during 1-18 days) promotes iPSC generation from human neonatal keratinocytes[2].
YO-01027 (2 μM, 3 days) does not affect p53 activity in OCT4, SOX2-transduced human keratinocytes[2].
YO-01027 (10 μM, 3 days) promotes the proliferation of supporting cells (SCs) in cultured mouse cochleae[3].
YO-01027 (10 μM, 3 days) generates new hair cell (HCs) and increases the HCs number in neonatal mouse cochleae[3].

分子量

463.48

Formula

C26H23F2N3O3

CAS 号

209984-56-5

中文名称

二苯并氮卓 (GMP)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.